Simple 1,2-Diamine Ligands for Asymmetric Addition of Aryllithium Reagents to Imines

Cabello, Noemi; Kizirian, Jean-Claude; Gille, Segolene; Alexakis, Alexandre; Bernardinelli, Gérald Hugues; Pinchard, Laurent; Caille, Jean-Claude

doi:10.1002/ejoc.200500447

Scientific article

English

Simple 1,2-Diamine Ligands for Asymmetric Addition of Aryllithium Reagents to Imines

ContributorsCabello, Noemi; Kizirian, Jean-Claude; Gille, Segolene; Alexakis, Alexandre; Bernardinelli, Gérald Hugues; Pinchard, Laurent; Caille, Jean-Claude

Published inEuropean journal of organic chemistry, vol. 2005, no. 22, p. 4835-4842

Publication date2005

Abstract

Enantioselective addition of various aryllithium reagents to aromatic imines was catalyzed (20 mol-%) by readily accessible 1,2-diamines to afford a wide range of protected diarylmethylamines in up to 94 % enantiomeric excess. Furthermore, the absolute configuration of these arylation products was determined by using X-ray crystallography.

Keywords

Diamines
Asymmetric 1,2-addition
Imines
Organolithium compounds

Affiliation

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

CABELLO, Noemi et al. Simple 1,2-Diamine Ligands for Asymmetric Addition of Aryllithium Reagents to Imines. In: European journal of organic chemistry, 2005, vol. 2005, n° 22, p. 4835–4842. doi: 10.1002/ejoc.200500447

Article (Published version)

Identifiers

PID : unige:8032
DOI : 10.1002/ejoc.200500447

ISSN of the journal1099-0690

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Simple 1,2-Diamine Ligands for Asymmetric Addition of Aryllithium Reagents to Imines

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