en
Scientific article
English

Asymmetric conjugate addition to α-halo enones : Dramatic effect of styrene on the enantioselectivity

Published inAngewandte Chemie, vol. 45, no. 45, p. 7600-7603
Publication date2006
Abstract

A simple trick could prove generally valuable for asymmetric copper-catalyzed conjugate addition reactions. It was found that the enantioselectivities of such reactions of dialkyl zinc reagents with α-halo enones in the presence of chiral phosphorimidite ligands were dramatically improved upon the addition of styrene, which acts as a radical scavenger to suppress the competitive non-asymmetric radical pathway (see example).

Keywords
  • Asymmetric synthesis
  • Conjugate addition
  • Copper
  • Homogeneous catalysis
  • Radicals
Citation (ISO format)
LI, Kangying, ALEXAKIS, Alexandre. Asymmetric conjugate addition to α-halo enones : Dramatic effect of styrene on the enantioselectivity. In: Angewandte Chemie, 2006, vol. 45, n° 45, p. 7600–7603. doi: 10.1002/anie.200602417
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1433-7851
744views
0downloads

Technical informations

Creation2010/06/21 14:15:38
First validation2010/06/21 14:15:38
Update time2023/03/14 15:47:42
Status update2023/03/14 15:47:42
Last indexation2024/01/15 20:25:40
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack