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Scientific article
English

Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis

Published inBrain, vol. 139, no. Pt 1, p. 39-46
Publication date2016
Abstract

See Friese (doi:10.1093/brain/awv349) for a scientific commentary on this article.Grey matter pathology has emerged as an important contributor to long-term disability in multiple sclerosis. To better understand where and how neuronal damage in the grey matter is initiated, we used high resolution confocal microscopy of Golgi-Cox impregnated tissue sections and reconstructed single cortical projection neurons in autopsies from eight patients with long-standing relapsing-remitting or secondary progressive multiple sclerosis and eight control patients without neurological disease. Analysis of several hundred individual neurons located in the insular, frontotemporal and occipital lobe revealed a widespread and pronounced loss of dendritic spines in multiple sclerosis cortex that occurs independent of cortical demyelination and axon loss. The presence of a primary synaptic pathology in the normal-appearing cortex of multiple sclerosis patients challenges current disease concepts and has important implications for our understanding of disease progression.

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Citation (ISO format)
JÜRGENS, Tanja et al. Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis. In: Brain, 2016, vol. 139, n° Pt 1, p. 39–46. doi: 10.1093/brain/awv353
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ISSN of the journal0006-8950
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Creation01/11/2016 6:55:00 PM
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