Novel biphenol phosphoramidite ligands for the enantioselective copper-catalyzed conjugate addition of dialkyl zincs

Alexakis, Alexandre; Rosset, Stéphane; Allamand, Janik; March, Sebastien; Guillen, Frédéric; Benhaim, Cyril

doi:10.1055/s-2001-16791

Scientific article

English

Novel biphenol phosphoramidite ligands for the enantioselective copper-catalyzed conjugate addition of dialkyl zincs

ContributorsAlexakis, Alexandre; Rosset, Stéphane; Allamand, Janik; March, Sebastien; Guillen, Frédéric; Benhaim, Cyril

Published inSynlett, no. 9, p. 1375-1378

Publication date2001

Abstract

Phosphoramidite ligands, based on a chiral amine and atropoisomerically flexible biphenols, induce high enantioselectivities (ee's up to 98%) in the copper-catalyzed conjugate addition of dialkyl zinc reagents to a variety of Michael acceptors.

Keywords

161 Biphenols Synlett 01.pdf
Asymmetric catalysis
Copper
Zinc
Michael additions
Phosphorus
Atropoisomerism

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

ALEXAKIS, Alexandre et al. Novel biphenol phosphoramidite ligands for the enantioselective copper-catalyzed conjugate addition of dialkyl zincs. In: Synlett, 2001, n° 9, p. 1375–1378. doi: 10.1055/s-2001-16791

Identifiers

PID : unige:6318
DOI : 10.1055/s-2001-16791

Journal ISSN0936-5214

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Novel biphenol phosphoramidite ligands for the enantioselective copper-catalyzed conjugate addition of dialkyl zincs

Phosphoramidite ligands, based on a chiral amine and atropoisomerically flexible biphenols, induce high enantioselectivities (ee's up to 98%) in the copper-catalyzed conjugate addition of dialkyl zinc reagents to a variety of Michael acceptors.

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