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Article scientifique
Anglais

HLA allele and haplotype frequencies in the Albanian population and their relationship with the other European populations

Publié dansInternational journal of immunogenetics, vol. 36, no. 6, p. 337-343
Date de publication2009
Résumé

Human leucocyte antigen (HLA) alleles are very interesting markers in identifying population relationships. Moreover, their frequency distribution data are important in the implementation of donor-recipient registry programs for transplantation purposes and also in determining the genetic predisposition for many diseases. For these reasons, we studied the HLA class I and II allele and haplotype frequencies in 160 healthy, unrelated Albanian individuals originating from all regions of the country. The HLA genotyping was performed through a 2-digit resolution SSOP method. The data were analysed with Arlequin and Phylip programs. No deviation was found from the Hardy-Weinberg equilibrium. A total of 17 A*, 30 B*, 12 Cw*, 13 DRB1* and 5 DQB1* alleles were identified. The six most frequent HLA-A-B-DRB1 haplotypes were A*02-B*18-DRB1*11 (5.60%), A*02-B*51-DRB1*16 (4.74%), A*01-B*08-DRB1*03 (3.48%), A*24-B*35-DRB1*11 (2.77%), A*02-B*51-DRB1*13 (2.21%), A*24-B*35-DRB1*14 (1.89%). Interestingly, 12 HLA-A-B-Cw-DRB1-DQB1 haplotypes occurred at a frequency >1%. When compared with the other populations, a close relationship was found with North Greek, Bulgarian, Macedonian, Romanian, Turkish, Cretan, Serbian, Croatian and Italian populations. A higher differentiation in allele frequency level was found with Western Europe populations. These data are the first report of HLA allele and haplotype distribution in an Albanian population inside this country. When compared with other populations, their distribution frequencies show close similarities with neighbouring populations of the entire Balkan area.

Mots-clés
  • Albanie
  • Europe
  • Génétique humaine
  • HLA
Groupe de recherche
Citation (format ISO)
SULCEBE, G. et al. HLA allele and haplotype frequencies in the Albanian population and their relationship with the other European populations. In: International journal of immunogenetics, 2009, vol. 36, n° 6, p. 337–343. doi: 10.1111/j.1744-313X.2009.00868.x
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Article (Published version)
accessLevelRestricted
Identifiants
ISSN du journal1744-313X
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Création15.12.2009 12:05:00
Première validation15.12.2009 12:05:00
Heure de mise à jour14.03.2023 15:19:40
Changement de statut14.03.2023 15:19:40
Dernière indexation15.01.2024 19:23:47
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