Timing of antiepileptic drug withdrawal and long-term seizure outcome after paediatric epilepsy surgery (TimeToStop): a retrospective observational study

Boshuisen, Kim; Arzimanoglou, Alexis; Cross, J Helen; Uiterwaal, Cuno S P M; Polster, Tilman; van Nieuwenhuizen, Onno; Braun, Kees P J; TimeToStop study group

doi:10.1016/S1474-4422(12)70165-5

Scientific article

English

Timing of antiepileptic drug withdrawal and long-term seizure outcome after paediatric epilepsy surgery (TimeToStop): a retrospective observational study

ContributorsBoshuisen, Kim; Arzimanoglou, Alexis; Cross, J Helen; Uiterwaal, Cuno S P M; Polster, Tilman; van Nieuwenhuizen, Onno; Braun, Kees P J; TimeToStop study group

CollaboratorsSeeck, Margitta

Published inLancet neurology, vol. 11, no. 9, p. 784-791

Publication date2012

Abstract

Postoperative antiepileptic drug (AED) withdrawal practices remain debatable and little is known about the optimum timing. We hypothesised that early AED withdrawal does not affect long-term seizure outcome but allows identification of incomplete surgical success earlier than late withdrawal. We aimed to assess the relation between timing of AED withdrawal and subsequent seizure recurrence and long-term seizure outcome.

Keywords

Anticonvulsants/therapeutic use
Child
Child, Preschool
Electroencephalography
Epilepsy/diagnosis/drug therapy/surgery
Europe/epidemiology
Female
Hemispherectomy/methods
Humans
Infant
Longitudinal Studies
Magnetic Resonance Imaging
Male
Proportional Hazards Models
Retrospective Studies
Time Factors

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

Research groups

Epilepsie et Chirurgie (149)

Citation (ISO format)

BOSHUISEN, Kim et al. Timing of antiepileptic drug withdrawal and long-term seizure outcome after paediatric epilepsy surgery (TimeToStop): a retrospective observational study. In: Lancet neurology, 2012, vol. 11, n° 9, p. 784–791. doi: 10.1016/S1474-4422(12)70165-5

Article (Published version)

Identifiers

PID : unige:45234
DOI : 10.1016/S1474-4422(12)70165-5
PMID : 22841352

Journal ISSN1474-4422

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Timing of antiepileptic drug withdrawal and long-term seizure outcome after paediatric epilepsy surgery (TimeToStop): a retrospective observational study

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