Influence of CRTC1 polymorphisms on body mass index and fat mass in psychiatric patients and the general adult population

Choong, Eva; Quteineh, Lina; Cardinaux, Jean-René; Gholam-Rezaee, Mehdi; Vandenberghe, Frederik; Dobrinas, Maria; Bondolfi, Guido; Etter, Manuela Ioana; Holzer, Laurent; Magistretti, Pierre; von Gunten, Armin; Preisig, Martin; Vollenweider, Peter; Beckmann, Jacques S.; Pralong, François Pierre; Waeber, Gerard; Kutalik, Zoltan; Conus, Philippe; Bochud, Murielle; Eap, Chin Bin

doi:10.1001/jamapsychiatry.2013.187

Scientific article

English

Influence of CRTC1 polymorphisms on body mass index and fat mass in psychiatric patients and the general adult population

Published inJAMA psychiatry, vol. 70, no. 10, p. 1011-1019

Publication date2013

Abstract

There is a high prevalence of obesity in psychiatric patients, possibly leading to metabolic complications and reducing life expectancy. The CREB-regulated transcription coactivator 1 (CRTC1) gene is involved in energy balance and obesity in animal models, but its role in human obesity is unknown.

Keywords

Adiposity/genetics
Adult
Body Mass Index
Case-Control Studies
Female
Genetic Predisposition to Disease/genetics
Humans
Male
Mental Disorders/complications/genetics
Obesity/complications/genetics
Polymorphism, Single Nucleotide
Transcription Factors/genetics

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de psychiatrie

Research groups

Médecine psychosomatique, neurosciences cliniques et mindfulness (690)

Citation (ISO format)

CHOONG, Eva et al. Influence of CRTC1 polymorphisms on body mass index and fat mass in psychiatric patients and the general adult population. In: JAMA psychiatry, 2013, vol. 70, n° 10, p. 1011–1019. doi: 10.1001/jamapsychiatry.2013.187

Article (Published version)

Identifiers

PID : unige:43122
DOI : 10.1001/jamapsychiatry.2013.187
PMID : 23925723

Journal ISSN2168-622X

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First validation10/12/2014 11:53:00

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Influence of CRTC1 polymorphisms on body mass index and fat mass in psychiatric patients and the general adult population

There is a high prevalence of obesity in psychiatric patients, possibly leading to metabolic complications and reducing life expectancy. The CREB-regulated transcription coactivator 1 (CRTC1) gene is involved in energy balance and obesity in animal models, but its role in human obesity is unknown.

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