Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length

Chuard, Nicolas; Gasparini, Giulio; Roux, Aurélien; Sakai, Naomi; Matile, Stefan

doi:10.1039/C4OB02060J

Article scientifique

Anglais

Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length

Contributeurs/tricesChuard, Nicolas; Gasparini, Giulio; Roux, Aurélien

; Sakai, Naomi; Matile, Stefan

Publié dansOrganic & biomolecular chemistry, vol. 13, no. 1, p. 64-67

Date de publication2015

Résumé

We report that the depolymerization kinetics of cell-penetrating poly(disulfide)s depend exclusively on their length and propose a kinetic uptake model to explain why their intracellular destination changes with the increasing length from the endosomes over the cytosol to the nucleoli.

Structure d'affiliation

Citation (format ISO)

CHUARD, Nicolas et al. Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length. In: Organic & biomolecular chemistry, 2015, vol. 13, n° 1, p. 64–67. doi: 10.1039/C4OB02060J

Article (Published version)

Identifiants

PID : unige:43002
DOI : 10.1039/C4OB02060J

URL commercialhttp://xlink.rsc.org/?DOI=C4OB02060J

ISSN du journal1477-0520

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Première validation05.12.2014 14:52:00

Heure de mise à jour14.03.2023 22:24:19

Changement de statut14.03.2023 22:24:19

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Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length

We report that the depolymerization kinetics of cell-penetrating poly(disulfide)s depend exclusively on their length and propose a kinetic uptake model to explain why their intracellular destination changes with the increasing length from the endosomes over the cytosol to the nucleoli.

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