Pd2Au36(SC2H4Ph)24 clusters have been prepared, isolated and separated in their enantiomers. Compared to the parent Au38(SC2H4Ph)24 cluster the doping leads to a significant change of the circular dichrosim spectrum, however, the anisotropy factors are of similar magnitude in both cases. Isolation of the enantiomers allowed us to study the racemi-zation of the chiral cluster, which reflects the flexibility of the ligand shell composed of staple motifs. The doping leads to a substantial lowering of the racemization temperature. The change in activation parameters due to the doping may be solely due to modification of the electronic structure.