Scientific article

English

Activity-dependent structural plasticity of perisynaptic astrocytic domains promotes excitatory synapse stability

ContributorsBernardinelli, Yann; Randall, Jérôme; Janett, Elia; Nikonenko, Iryna; Konig, Stéphane

; Jones, Emma Victoria; Flores Nakandakare, Carmen Estela; Murai, Keith K; Bochet, Christian G; Holtmaat, Anthony

; Muller, Dominique

Published inCurrent biology, vol. 24, no. 15, p. 1679-1688

Publication date2014

Abstract

Excitatory synapses in the CNS are highly dynamic structures that can show activity-dependent remodeling and stabilization in response to learning and memory. Synapses are enveloped with intricate processes of astrocytes known as perisynaptic astrocytic processes (PAPs). PAPs are motile structures displaying rapid actin-dependent movements and are characterized by Ca(2+) elevations in response to neuronal activity. Despite a debated implication in synaptic plasticity, the role of both Ca(2+) events in astrocytes and PAP morphological dynamics remain unclear.

Affiliation

Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

Research group

Plasticité des synapses excitatrices (76)

Citation (ISO format)

BERNARDINELLI, Yann et al. Activity-dependent structural plasticity of perisynaptic astrocytic domains promotes excitatory synapse stability. In: Current biology, 2014, vol. 24, n° 15, p. 1679–1688. doi: 10.1016/j.cub.2014.06.025

Article (Published version)

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Identifiers

PID : unige:40329
DOI : 10.1016/j.cub.2014.06.025
PMID : 25042585

ISSN of the journal0960-9822

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