Resorcylic acid lactones: A pluripotent scaffold with therapeutic potential

Barluenga, Sofia; Dakas, Pierre-Yves; Boulifa, Mehdi; Moulin, Emilie; Winssinger, Nicolas

doi:10.1016/j.crci.2008.01.020

Scientific article

English

Resorcylic acid lactones: A pluripotent scaffold with therapeutic potential

ContributorsBarluenga, Sofia; Dakas, Pierre-Yves; Boulifa, Mehdi; Moulin, Emilie; Winssinger, Nicolas

Published inComptes rendus. Chimie, vol. 11, no. 11-12, p. 1306-1317

Publication date2008

Abstract

The recent discoveries of potent HSP90 and MAP kinase inhibitors amongst the resorcylic acid lactones (RALs) have revived interest in this family of natural products. Both HSP90 and MAP kinase inhibition hold tremendous therapeutic potential, particularly in the treatment of cancer. Our synthetic efforts towards the RALs and, in particular, selective inhibitors of HSP90 and kinases are reviewed.

Keywords

Resorcylic acid lactones (RALs)
Kinase inhibitors
HSP90
Total synthesis
Combinatorial synthesis
Solid-phase synthesis
Polymer supported reagents

Affiliation entities

Not a UNIGE publication

Citation (ISO format)

BARLUENGA, Sofia et al. Resorcylic acid lactones: A pluripotent scaffold with therapeutic potential. In: Comptes rendus. Chimie, 2008, vol. 11, n° 11-12, p. 1306–1317. doi: 10.1016/j.crci.2008.01.020

Article (Published version)

Identifiers

PID : unige:24722
DOI : 10.1016/j.crci.2008.01.020

Additional URL for this publicationhttp://linkinghub.elsevier.com/retrieve/pii/S163107480800101X

Journal ISSN1631-0748

677views

0downloads

Creation12/12/2012 09:10:00

First validation12/12/2012 09:10:00

Update time14/03/2023 17:47:52

Status update14/03/2023 17:47:52

Last indexation30/10/2024 08:05:42

Archive ouverte UNIGE

Resorcylic acid lactones: A pluripotent scaffold with therapeutic potential

Technical informations