Concise Modular Asymmetric Synthesis of Deguelin, Tephrosin and Investigation into Their Mode of Action

Garcia, José; Barluenga, Sofia; Beebe, Kristin; Neckers, Len; Winssinger, Nicolas

doi:10.1002/chem.201001080

Scientific article

English

Concise Modular Asymmetric Synthesis of Deguelin, Tephrosin and Investigation into Their Mode of Action

ContributorsGarcia, José; Barluenga, Sofia; Beebe, Kristin; Neckers, Len; Winssinger, Nicolas

Published inChemistry, vol. 16, no. 32, p. 9767-9771

Publication date2010

Abstract

The concise nature and modularity of the synthesis described for deguelin and tephrosin (retrosynthetic analysis depicted) should facilitate access to labeled analogues to dissect the mechanism of action of this important pharmacophore.

Keywords

deguelin
Hsp90
natural products
tephrosin
total synthesis

Affiliation entities

Not a UNIGE publication

Citation (ISO format)

GARCIA, José et al. Concise Modular Asymmetric Synthesis of Deguelin, Tephrosin and Investigation into Their Mode of Action. In: Chemistry, 2010, vol. 16, n° 32, p. 9767–9771. doi: 10.1002/chem.201001080

Article (Published version)

Identifiers

PID : unige:24702
DOI : 10.1002/chem.201001080

Journal ISSN0947-6539

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Concise Modular Asymmetric Synthesis of Deguelin, Tephrosin and Investigation into Their Mode of Action

The concise nature and modularity of the synthesis described for deguelin and tephrosin (retrosynthetic analysis depicted) should facilitate access to labeled analogues to dissect the mechanism of action of this important pharmacophore.

Technical informations