Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries

Daguer, Jean-Pierre; Ciobanu, Mihai; Barluenga, Sofia; Winssinger, Nicolas

doi:10.1039/c2ob06880j

Scientific article

English

Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries

ContributorsDaguer, Jean-Pierre; Ciobanu, Mihai; Barluenga, Sofia; Winssinger, Nicolas

Published inOrganic & biomolecular chemistry, vol. 10, no. 8, p. 1502-1505

Publication date2012

Abstract

Dehydrocholic acid was identified as a selective streptavidin binder from a PNA-tagged library. Isothermal calorimetry titration measurements showed this interaction to be entropically driven. Peptides tagged with dehydrocholic acid can be captured on a streptavidin resin and released under thermal conditions.

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Not a UNIGE publication

Citation (ISO format)

DAGUER, Jean-Pierre et al. Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries. In: Organic & biomolecular chemistry, 2012, vol. 10, n° 8, p. 1502–1505. doi: 10.1039/c2ob06880j

Article (Published version)

Identifiers

PID : unige:24671
DOI : 10.1039/c2ob06880j

Additional URL for this publicationhttp://xlink.rsc.org/?DOI=c2ob06880j

Journal ISSN1477-0520

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Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries

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