From Split-Pool Libraries to Spatially Addressable Microarrays and Its Application to Functional Proteomic Profiling

Winssinger, Nicolas; Harris, Jennifer L.; Backes, Bradley J.; Schultz, Peter G.

doi:10.1002/1521-3773(20010903)40:17<3152::AID-ANIE3152>3.0.CO;2-P

Scientific article

English

From Split-Pool Libraries to Spatially Addressable Microarrays and Its Application to Functional Proteomic Profiling

ContributorsWinssinger, Nicolas; Harris, Jennifer L.; Backes, Bradley J.; Schultz, Peter G.

Published inAngewandte Chemie, vol. 40, no. 17, p. 3152-3155

Publication date2001

Abstract

Small molecules encoded with peptidonucleic acid (PNA) were used to probe protein function in a microarray format. The PNA tag served to encode the synthetic history of the small molecule and to positionally encode the identity of the small molecule by its location upon hybridization to an oligonucleotide microarray (see picture).

Keywords

combinatorial chemistry
cysteine protease
functional genomics
hydrolases
split-pool synthesis

Affiliation entities

Not a UNIGE publication

Citation (ISO format)

WINSSINGER, Nicolas et al. From Split-Pool Libraries to Spatially Addressable Microarrays and Its Application to Functional Proteomic Profiling. In: Angewandte Chemie, 2001, vol. 40, n° 17, p. 3152–3155. doi: 10.1002/1521-3773(20010903)40:17<3152::AID-ANIE3152>3.0.CO;2-P

Article (Published version)

Identifiers

PID : unige:24526
DOI : 10.1002/1521-3773(20010903)40:17<3152::AID-ANIE3152>3.0.CO;2-P

Journal ISSN1433-7851

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From Split-Pool Libraries to Spatially Addressable Microarrays and Its Application to Functional Proteomic Profiling

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