Expanding the scope of PNA-encoded libraries: divergent synthesis of libraries targeting cysteine, serine and metallo-proteases as well as tyrosine phosphatases

Debaene, François; Da Silva, Julien A.; Pianowski, Zbigniew; Duran, Fernando J.; Winssinger, Nicolas

doi:10.1016/j.tet.2007.03.033

Scientific article

English

Expanding the scope of PNA-encoded libraries: divergent synthesis of libraries targeting cysteine, serine and metallo-proteases as well as tyrosine phosphatases

ContributorsDebaene, François; Da Silva, Julien A.; Pianowski, Zbigniew; Duran, Fernando J.; Winssinger, Nicolas

Published inTetrahedron, vol. 63, no. 28, p. 6577-6586

Publication date2007

Abstract

Seven PNA-encoded combinatorial libraries targeting proteases and phosphatases with covalent reversible and irreversible mechanism-based inhibitors were prepared. The libraries were synthesized using modified PNA monomers, which dramatically increase the water solubility of the libraries in biologically relevant buffers. The libraries were shown to selectively inhibit targeted enzymes.

Keywords

PNA
Protease inhibitors
Phosphatase inhibitors
Combinatorial chemistry
Microarrays

Affiliation entities

Not a UNIGE publication

Citation (ISO format)

DEBAENE, François et al. Expanding the scope of PNA-encoded libraries: divergent synthesis of libraries targeting cysteine, serine and metallo-proteases as well as tyrosine phosphatases. In: Tetrahedron, 2007, vol. 63, n° 28, p. 6577–6586. doi: 10.1016/j.tet.2007.03.033

Article (Published version)

Identifiers

PID : unige:24503
DOI : 10.1016/j.tet.2007.03.033

Additional URL for this publicationhttp://linkinghub.elsevier.com/retrieve/pii/S004040200700395X

Journal ISSN0040-4020

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Expanding the scope of PNA-encoded libraries: divergent synthesis of libraries targeting cysteine, serine and metallo-proteases as well as tyrosine phosphatases

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