Asymmetric synthesis of ethano-Tröger bases using CuTC-catalyzed diazo decomposition reactions

Sharma, Ankit; Besnard, Céline; Guenee, Laure; Lacour, Jérôme

doi:10.1039/c1ob06751f

Scientific article

English

Asymmetric synthesis of ethano-Tröger bases using CuTC-catalyzed diazo decomposition reactions

ContributorsSharma, Ankit; Besnard, Céline; Guenee, Laure; Lacour, Jérôme

Published inOrganic & biomolecular chemistry, vol. 10, no. 5, p. 966-969

Publication date2012

Abstract

Nonracemic ethano-bridged Tröger bases are prepared using CuTC-catalyzed decompositions of diazo compounds. Excellent levels of diastereo- and enantio-control (dr and ee up to 12:1 and 95% respectively) are now obtained with aryl diazoketone precursors.

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

SHARMA, Ankit et al. Asymmetric synthesis of ethano-Tröger bases using CuTC-catalyzed diazo decomposition reactions. In: Organic & biomolecular chemistry, 2012, vol. 10, n° 5, p. 966–969. doi: 10.1039/c1ob06751f

Article (Published version)

Identifiers

PID : unige:18072
DOI : 10.1039/c1ob06751f

Additional URL for this publicationhttp://xlink.rsc.org/?DOI=c1ob06751f

Journal ISSN1477-0520

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Asymmetric synthesis of ethano-Tröger bases using CuTC-catalyzed diazo decomposition reactions

Nonracemic ethano-bridged Tröger bases are prepared using CuTC-catalyzed decompositions of diazo compounds. Excellent levels of diastereo- and enantio-control (dr and ee up to 12:1 and 95% respectively) are now obtained with aryl diazoketone precursors.

Technical informations