Spectral aliasing consists in setting the spectral window of multidimensional NMR experiments below the full range of chemical shifts in order to increase the spectral resolution. The improvement factor can reach two orders of magnitude when applied to small molecules. The ambiguities in the observed chemical shifts can be resolved using diverse sources of complementary information discussed in the article. The advantages of spectral aliasing are very easy implementation with almost any standard pulse sequence, and reliance on the classical linear sampling of data points processed using the Fourier transform. Applications to small molecules and proteins are discussed.