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Title

Access to High Levels of Molecular Complexity by One-Pot Iridium/Enamine Asymmetric Catalysis

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Published in Angewandte Chemie: International Edition. 2011, vol. 50, no. 10, p. 2354 - 2358
Abstract Independent workers with team spirit: A catalytic sequence that exploits the compatibility of (chiral) cationic iridium catalysts for the isomerization of primary allylic alcohols to aldehydes with organocatalysts has been developed for the highly enantioselective α functionalization of aldehydes (see scheme: up to 66 % yield, d.r. 49:1, 99 % ee). The reaction displayed useful generality with respect to both the nucleophile and the electrophile.
Keywords Asymmetric catalysisIridiumIsomerizationOne-pot reactionsOrganocatalysis
Stable URL http://archive-ouverte.unige.ch/unige:14494
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Other version: http://doi.wiley.com/10.1002/anie.201007001
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Deposited on : 2011-02-24

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