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Orodigital pemphigus vulgaris: a pathogenic role of anti-desmoglein-3 autoantibodies in pemphigus paronychia?
|Published in||Dermatology. 2008, vol. 217, no. 4, p. 337-9|
|Abstract||Paronychia is a rare complication of pemphigus vulgaris (PV), and the immunological profile of patients with digital disease has not been assessed so far. We report 2 cases of PV with oral mucosa and periungual involvement, who had high titers of anti- desmoglein (Dsg)-3 circulating antibodies. These observations raise the possibility that expression of Dsg-1 and Dsg-3 in distinct areas of periungual skin is disease specific and that anti-Dsg-3 antibodies alone may have an as yet unrecognized importance for the development of paronychia in PV.|
|Keywords||Aged — Autoantibodies/blood — Biological Markers/blood — Desmoglein 1/immunology — Desmoglein 3/immunology — Enzyme-Linked Immunosorbent Assay — Female — Fingers — Humans — Middle Aged — Mouth Diseases/immunology/pathology — Mouth Mucosa/pathology — Paronychia/immunology — Pemphigus/immunology/pathology — Toes|