UNIGE document Scientific Article
previous document  unige:13245  next document
add to browser collection
Title

The chick embryo and its chorioallantoic membrane (CAM) for the in vivo evaluation of drug delivery systems

Authors
Vargas, Angelica
Delie, Florence
Published in Advanced Drug Delivery Reviews. 2007, vol. 59, no. 11, p. 1162-76
Abstract Mammalian models are frequently used for preclinical evaluation of new drug delivery systems (DDS). However, valid mammalian models are expensive, time-consuming, and not easy to set up and evaluate. Furthermore, they are often linked to administrative burden with respect to ethical and legal aspects. The present review outlines the possibilities and limitations of using the hen's embryo, and specifically its chorioallantoic membrane (CAM), as an alternative to mammalian models for the evaluation of DDS. Features of the CAM, the anatomy of the embryo, and the blood were investigated to assess properties of the drug carriers such as toxicity and biocompatibility, as well as the activity, toxicity, biodistribution and pharmacokinetics of the drug. The simplicity, rapidity, and low cost of the different assays that can be performed with chick embryos strengthen the interest of routinely using this model in pharmaceutical technology research. It is concluded that there is a big potential for using chick embryos in screening procedures of formulation candidates, thus establishing an intermediate step between in vitro cellular tests and preclinical mammalian models.
Keywords Angiogenesis Inhibitors/pharmacologyAnimalsBiosensing TechniquesChemistry, PharmaceuticalChick Embryo/drug effects/metabolismChorioallantoic Membrane/drug effects/metabolismDrug Delivery SystemsNeovascularization, Physiologic/drug effectsOrgan Culture TechniquesPhotosensitizing Agents/pharmacologyTissue Distribution
Stable URL http://archive-ouverte.unige.ch/unige:13245
Full text
Article (Published version) (643 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Identifiers
PMID: 17870202
Structures

201 hits

2 downloads

Update

Deposited on : 2011-01-24

Export document
Format :
Citation style :