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Title

Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation

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Published in American Journal of Transplantation. 2008, vol. 8, no. 12, p. 2674-2683
Abstract Cytomegalovirus (CMV) infection is the most common viral complication after solid organ transplantation (SOT). Whilst current immunosuppression is known to impair antiviral-specific T-cell immunity in SOT, a potential role for natural killer (NK) cells not affected by immunosuppressive therapy remains to be determined. To address this, we compared the genotype of the NK immunoglobulin-like receptor (KIR) genes and their HLA cognate ligands to the rate of CMV infection in 196 kidney transplant recipients. We have shown that the absence of the HLA-C ligand for inhibitory KIR and the presence of activating KIR genes in the recipients were both associated with a lower rate of CMV infection after transplantation. In a cohort of 17 recipients with acute CMV infection, NK cells were phenotyped over a period of time after diagnosis by their expression profile of C-type lectin receptors and capacity to secrete IFN-gamma. The increased expression of the activating C-type lectin receptors NKG2C and NKG2D was paralleled by the decreased IFN-gamma secretion during the early phase of CMV infection. In conclusion, our findings suggest that KIR/HLA genotype and expression of NKG2C and NKG2D might play a significant role in regulating NK cell function and anti-CMV immunity after kidney transplantation.
Keywords AdultCytomegalovirus/immunologyCytomegalovirus Infections/epidemiology/immunologyFemaleGenotypeHLA-C Antigens/genetics/metabolismHumansInterferon-gamma/metabolismKidney Transplantation/immunologyKiller Cells, Natural/physiologyLectins, C-Type/genetics/metabolismLigandsMaleMiddle AgedNK Cell Lectin-Like Receptor Subfamily C/genetics/metabolismNK Cell Lectin-Like Receptor Subfamily K/genetics/metabolismPostoperative ComplicationsReceptors, KIR/genetics/metabolismReceptors, Natural Killer Cell/genetics/metabolismRetrospective StudiesRisk Factors
Stable URL http://archive-ouverte.unige.ch/unige:1270
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PMID: 19032228
Structures
Research groups Groupe Pierre-Yves Martin (néphrologie) (30)
Cultures cellulaires et transplantations (519)
Transplantation Immunologie et Osteoimmunologie (561)
Compatibilité tissulaire et transplantation clinique (562)
La transplantation d'îlots de Langerhans (623)
Groupe Laurent Kaiser (virologie clinique) (668)

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Deposited on : 2009-03-31

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