Peptide nucleic acids: synthesis, cellular uptake, encoding and templated reaction

Saarbach, Jacques

doi:10.13097/archive-ouverte/unige:126829

Doctoral thesis

English

Peptide nucleic acids: synthesis, cellular uptake, encoding and templated reaction

ContributorsSaarbach, Jacques

DirectorsWinssinger, Nicolas

Defense date2019-10-25

Abstract

In this work, a PNA synthetic methodology taking advantage of the Ugi four component reaction is described. Novel strategies for improving PNA cellular uptake are explored. PNA encoded libraries were screened against p97 and Akt/mSin1. Finally protein kinases were used to template an abiotic reaction.

Keywords

PNA
Templated reactions
Cellular uptake

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Research groups

Groupe Winssinger

Citation (ISO format)

SAARBACH, Jacques. Peptide nucleic acids: synthesis, cellular uptake, encoding and templated reaction. Doctoral Thesis, 2019. doi: 10.13097/archive-ouverte/unige:126829

Thesis

Identifiers

PID : unige:126829
DOI : 10.13097/archive-ouverte/unige:126829
URN : urn:nbn:ch:unige-1268291
Thesis number : Sc. 5405

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Creation22/11/2019 15:34:00

First validation22/11/2019 15:34:00

Update time15/03/2023 18:26:06

Status update15/03/2023 18:26:05

Last indexation31/10/2024 17:00:21

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Peptide nucleic acids: synthesis, cellular uptake, encoding and templated reaction

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