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Title

Strand separation in negatively supercoiled dna

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Published in Journal of Mathematical Biology. 2005, vol. 51, no. 2, p. 198-216
Abstract We consider Benham's model for strand separation in negatively supercoiled circular DNA, and study denaturation as function of the superhelical density k < 0. We propose a statistical version of this model, based on bayesian segmentation methods of current use in bioinformatics; this leads to new algorithms with priors adapted to supercoiled DNA, taking into account the random nature of the free energies needed to denature hydrogen bonds.
Note 20 pages
Stable URL http://archive-ouverte.unige.ch/unige:12151
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Deposited on : 2010-10-19

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