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New phenolic radical scavengers from Saxifraga cuneifolia

Chevalley, Isabelle
Marston, Andrew
Published in Pharmaceutical Biology. 2000, vol. 38, no. 3, p. 222-228
Abstract Thirteen compounds have been isolated from the methanol extract of Saxifraga cuneifolia L. (Saxifragaceae) whole plant. These were identified as five new compounds, (E)-5-O-beta-D-glucopyranosyl-stilbene-3,3', 4,5'-tetraol, (E)-4-O-beta-D-glucopyranosyl-5-methoxy- stilbene-3,3',5'-triol, 4-[ 4'-O-(6''-O-galloyl-beta-D-glucopyranosyl)- 3'-hydroxyphenyl] butan-2-one, 3-O( 6''-O-galloyl-beta-D-glucopyranosyl)-epigallocatechin and 3-O-beta-D-glucopyranosyl-epigallocatechin, together with the known compounds 4-[4'-O-beta-D-glucopyranosyl- 3'-hydroxyphenyl]-butan-2-one, (R) rhododendrin, 1-O-galloyl-beta-D-glucose, catechin, 3-O-galloyl-epigallocatechin, gallocatechin, clitorin and rutin, by chemical and spectroscopic methods. Their free radical scavenging properties are also described.
Keywords catechin derivativesflavonoid glycosidesfree radical scavengersphenylbutan2-one glycosides(r)-rhododendrinsaxifraga cuneifoliasaxifragaceaestilbene glycosidesacidantioxidantresveratroltannins
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