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A new potent antifungal 'quinone methide' diterpene with a cassane skeleton from Bobgunnia madagascariensis

Schaller, F.
Rahalison, L.
Islam, N.
Potterat, O.
Stoeckli-Evans, H.
Mavi, S.
Published in Helvetica Chimica Acta. 2000, vol. 83, p. 407-413
Abstract A new 'quinone methide' diterpene with a cassane skeleton was isolated from the root bark of Bobgunnia madagascariensis (DESV.) J.H. KIRKBR. et WIERSEMA (Leguminosae). Its structure was established as (4bS,8aS)-4b,5,6,7,8,8a-hexahydro-4-hydroxy-2-(2-hydroxyethyl)-1,4b,8,8-tetramethylphenathrene-3,9-dione by spectroscopic methods including single-crystal X-ray analysis. This compound showed strong antifungal properties towards human pathogenic fungi, in particular the yeast Candida albicans.
Keywords Bobgunnia madagascariensis (DESVsingle-crystal X-ray analysisantifungal properties.
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