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F-18 fluorodeoxyglucose (FDG) PET in the diagnosis of malignant transformation of fibrous dysplasia in the pelvic bones

Berrebi, Olivier
Steiner, Charles
Keller, A.
Published in Clinical Nuclear Medicine. 2008, vol. 33, no. 7, p. 469-71
Abstract Fibrous dysplasia (FD) is a benign dysplastic pathology of bone-forming mesenchymal cells, resulting in replacement of trabecular bone by abnormal fibrous and immature osseous tissue. FD can be either monostotic or polyostotic, is more often unilateral, and can be part of the McCune-Albright syndrome (MIM 174800). Sarcomatous degeneration in FD is rare, ranging from less than 1% in monostotic forms to 4% in the McCune-Albright syndrome. We report the case of a 59-year-old woman with monostotic FD of the left ischium, known for over 30 years, who developed sarcomatous transformation in a low-grade spindle-cell sarcoma. The value of F-18 fluorodeoxyglucose positron emission tomography in the early diagnosis of malignant transformation, the evaluation of distant metastasis, as well as monitoring the efficacy of chemotherapy are discussed.
Keywords Bone and Bones/radionuclide imagingCell ProliferationCell Transformation, NeoplasticFatal OutcomeFemaleFibrous Dysplasia of Bone/diagnosis/radionuclide imagingFluorodeoxyglucose F18/diagnostic useHumansMiddle AgedNeoplasm MetastasisPelvis/pathology/radionuclide imagingPositron-Emission Tomography/methodsRadiopharmaceuticals/diagnostic useSarcoma/diagnosis
Stable URL http://archive-ouverte.unige.ch/unige:1172
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PMID: 18580231
Research group Groupe Ratib Osman (nouvelles techniques d'imagerie moléculaire) (819)
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