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Coumarins from Peucedanum ostruthium as Inhibitors of Acetylcholinesterase

Marston, Andrew
Published in Pharmaceutical Biology. 2005, vol. 43, no. 8, p. 647 - 650
Abstract Different plant extracts have been screened by thin-layer chromatography (TLC) bioautography in an effort to discover new acetylcholinesterase (AChE) inhibitors. The CH2 Cl-2 extract of Peucedanum ostruthium (L.) Koch roots exhibited significant inhibition of AChE-l activity. Active constituents were isolated by bioguided fractionation using almost exclusively centrifugal partition chromatography. Four coumarins (ostruthin, imperatorin, ostruthol, and oxypeucedanin hydrate) and a chromone derivative (peucenin) were found to inhibit AChE activity in this bioassay.
Keywords Acetylcholinesterase inhibitorsBioautographyCentrifugal partition chromatographyCoumarinsPeucedanum ostruthium
Stable URL http://archive-ouverte.unige.ch/unige:11665
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