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Bio-guided isolation of cholinesterase inhibitors from the bulbs of Crinum x powellii

Kissling, Jonathan
Ioset, Jean-Robert
Marston, Andrew
Published in Phytotherapy Research. 2005, vol. 19, no. 11, p. 984 - 987
Abstract In a search for potential acetylcholinesterase (AChE) inhibitors, the ethanol extract of the bulbs of Crinum X powellii (Amaryllidaceae) was found to demonstrate a marked inhibition of this enzyme. Using a bio-guided isolation strategy, linoleic acid ethyl ester has been identified as the compound responsible for this inhibition. Three other molecules - the alkaloid hippadine, the glycosylated benzyl alcohol derivative calleryanin and 4'-hydroxy-7-methoxyflavan - were also isolated and characterized for the first time from Crinum x powellii. The structures of these compounds were elucidated by spectrometric methods including EI, D/CI mass spectrometry, H-1, C-13 and 2D NMR experiments. Linoleic acid was also found to inhibit AChE.
Stable URL http://archive-ouverte.unige.ch/unige:11658
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Other version: http://doi.wiley.com/10.1002/ptr.1770
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