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Molecular defects in the bare lymphocyte syndrome and regulation of MHC class II genes

Published in Immunology Today. 1995, vol. 16, no. 11, p. 539-546
Abstract The complex pattern of expression of major histocompatibility complex (MHC) class II molecules plays an essential role in the control of the immune response. Our understanding of the molecular mechanisms controlling this expression has benefited greatly from the identification of the regulatory factors defective in two forms of a hereditary disease of MHC class II regulation: bare lymphocyte syndrome. This has also provided new tools for the experimental modulation of MHC class II expression.
Keywords Gene Expression Regulation/ immunologyGenes, MHC Class II/ immunologyHumansSevere Combined Immunodeficiency/ genetics
Stable URL http://archive-ouverte.unige.ch/unige:11542
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PMID: 7495492
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