UNIGE document Scientific Article
previous document  unige:11528  next document
add to browser collection

Cytostatic drugs differentially affect phenotypic features of porcine coronary artery smooth muscle cell populations

Jayaraman, Swaminathan
Galloni, Marco
Van Eys, Guillaume
Published in FEBS Letters. 2007, vol. 581, no. 30, p. 5847-5851
Abstract We studied the effects of cytostatic drugs on porcine coronary artery spindle-shaped (S) and rhomboid (R) smooth muscle cell (SMC) biological activities related to intimal thickening (IT) formation. Imatinib, and to a lesser extent curcumin, decreased proliferation of S- and R-SMCs and migratory and urokinase activities of R-SMCs more efficiently compared with cyclosporine plus rapamycin. Imatinib increased the expression of alpha-smooth muscle actin in both SMC populations and that of smoothelin in S-SMCs. It decreased S100A4 expression in R-SMCs. By promoting SMC quiescence and differentiation imatinib and curcumin may represent valid candidates for restenosis preventive and therapeutic strategies.
Keywords AnimalsBiological Markers/metabolismCell Differentiation/drug effectsCell Movement/drug effectsCell Proliferation/drug effectsCoronary Vessels/ cytology/ drug effects/enzymologyCytostatic Agents/ pharmacologyImmunoblottingMyocytes, Smooth Muscle/ cytology/ drug effects/enzymologyPhenotypeS100 Proteins/metabolismSwineUrokinase-Type Plasminogen Activator/metabolism
Stable URL http://archive-ouverte.unige.ch/unige:11528
Full text
PMID: 18053813
105 hits and 0 download since 2010-08-27
Export document
Format :
Citation style :