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Cytostatic drugs differentially affect phenotypic features of porcine coronary artery smooth muscle cell populations
|Published in||FEBS Letters. 2007, vol. 581, no. 30, p. 5847-5851|
|Abstract||We studied the effects of cytostatic drugs on porcine coronary artery spindle-shaped (S) and rhomboid (R) smooth muscle cell (SMC) biological activities related to intimal thickening (IT) formation. Imatinib, and to a lesser extent curcumin, decreased proliferation of S- and R-SMCs and migratory and urokinase activities of R-SMCs more efficiently compared with cyclosporine plus rapamycin. Imatinib increased the expression of alpha-smooth muscle actin in both SMC populations and that of smoothelin in S-SMCs. It decreased S100A4 expression in R-SMCs. By promoting SMC quiescence and differentiation imatinib and curcumin may represent valid candidates for restenosis preventive and therapeutic strategies.|
|Keywords||Animals — Biological Markers/metabolism — Cell Differentiation/drug effects — Cell Movement/drug effects — Cell Proliferation/drug effects — Coronary Vessels/ cytology/ drug effects/enzymology — Cytostatic Agents/ pharmacology — Immunoblotting — Myocytes, Smooth Muscle/ cytology/ drug effects/enzymology — Phenotype — S100 Proteins/metabolism — Swine — Urokinase-Type Plasminogen Activator/metabolism|