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Pioglitazone in chronic hepatitis C not responding to pegylated interferon-alpha and ribavirin

Overbeck, Kathrin
Published in Journal of Hepatology. 2008, vol. 49, no. 2, p. 295-8
Abstract BACKGROUND/AIMS: Insulin resistance reduces the response to interferon alfa-based therapy of chronic hepatitis C patients. It has been speculated that improvement of insulin sensitivity might increase the chances of responding to treatment of such individuals. METHODS: We started a multicenter clinical trial of retreatment of chronic hepatitis C patients, who had failed to respond to the pegylated interferon alfa/ribavirin combination, with a triple therapy consisting in these same antivirals plus an insulin-sensitizer (pioglitazone) (The INSPIRED-HCV study). RESULTS: None of the first five patients fulfilling the inclusion criteria and included in the trial achieved a satisfactory virological response after 12 weeks of retreatment, despite the fact that in at least three of them the insulin resistance score improved. As a result, the study was terminated. CONCLUSIONS: Different schedules are warranted to improve insulin sensitivity prior to attempting retreatment of chronic hepatitis C patients with insulin resistance.
Keywords Antiviral Agents/administration & dosageDrug Resistance, ViralDrug Therapy, CombinationFemaleHepatitis C, Chronic/drug therapy/metabolismHumansHypoglycemic Agents/administration & dosageInsulin ResistanceInterferon Alfa-2a/administration & dosageMaleMiddle AgedPolyethylene Glycols/administration & dosageRibavirin/administration & dosageThiazolidinediones/administration & dosage
Stable URL http://archive-ouverte.unige.ch/unige:1143
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PMID: 18555553
Research groups Etudes et traitement de l'hépatite C et B (554)
Education thérapeutique du patient, diabète et obésité (600)
Swiss Association for the Study of the Liver (SASL)
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