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Variability of the inhibition by total immunoglobulin of in vitro autoantibody-mediated erythrophagocytosis by mouse macrophages

Leonard, S.
Pierard, I.
Michaelsen, T. E.
Masson, P. L.
Coutelier, Jean-Paul
Published in Clinical and Experimental Immunology. 2006, vol. 145, no. 1, p. 155-161
Abstract Several autoimmune diseases, mainly autoantibody-mediated, are attenuated by infusion of total IgG (IVIg). The efficacy varies widely from one patient to another. Using an experimental model of in vitro phagocytosis of autoantibody-coated erythrocytes by mouse macrophages, we analysed the possible causes for such a variability. Our results indicated that the efficacy of the phagocytosis inhibition depends upon different factors, such as the isotype and the extent of polymerization of the immunoglobulin used for the treatment as well as the genetic background of the mice and the state of macrophage activation that can be influenced by concomitant viral infection. The development of an in vitro assay for the phagocytic activity of macrophages might improve the selection of patients susceptible to benefit from IVIg treatment.
Keywords AnimalsAutoantibodies/*immunologyAutoimmune Diseases/immunology/*therapyCells, CulturedErythrocytes/*pathologyFemaleImmunoglobulin Fc Fragments/administration & dosageImmunoglobulin G/administration & dosageImmunoglobulin Isotypes/*administration & dosageImmunoglobulins, Intravenous/*administration & dosageMacrophages, Peritoneal/*physiologyMiceMice, Inbred BALB CMice, Inbred C3HModels, AnimalPhagocytosisPolymersSpecies Specificity
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PMID: 16792686
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