Article - Limited access to UNIGE
Other version: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T36-44P8JPX-97-1&_cdi=4938&_user=779890&_pii=00145793918080...
|Published in||FEBS Letters. 1991, vol. 285, no. 2, p. 225-229|
|Abstract||Intracellular Ca(2+)-storage organelles are found in virtually all eukaryotic cells. They play an important role in the regulation of the cytosolic free Ca2+ concentration and, thereby, in the regulation of cellular activity. Ca(2+)-storage organelles consist, in the simplest model of a Ca2+ pump, of a Ca(2+)-storage protein and a Ca(2+)-release channel. The primary structure of these functionally important proteins of Ca(2+)-storage organelles is similar in different cell types and conserved through evolution. In contrast, their spatial arrangement and, thus, the architecture of Ca(2+)-storage organelles may vary dramatically from one cell type to another.|
|Keywords||Biological Transport, Active — Calcium/ metabolism — Calcium Channels/metabolism — Calcium-Binding Proteins/ metabolism — Calreticulin — Calsequestrin/metabolism — Endoplasmic Reticulum — Models, Biological — Organelles/ metabolism — Sarcoplasmic Reticulum|