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Ca(2+)-storage organelles

Published in FEBS Letters. 1991, vol. 285, no. 2, p. 225-229
Abstract Intracellular Ca(2+)-storage organelles are found in virtually all eukaryotic cells. They play an important role in the regulation of the cytosolic free Ca2+ concentration and, thereby, in the regulation of cellular activity. Ca(2+)-storage organelles consist, in the simplest model of a Ca2+ pump, of a Ca(2+)-storage protein and a Ca(2+)-release channel. The primary structure of these functionally important proteins of Ca(2+)-storage organelles is similar in different cell types and conserved through evolution. In contrast, their spatial arrangement and, thus, the architecture of Ca(2+)-storage organelles may vary dramatically from one cell type to another.
Keywords Biological Transport, ActiveCalcium/ metabolismCalcium Channels/metabolismCalcium-Binding Proteins/ metabolismCalreticulinCalsequestrin/metabolismEndoplasmic ReticulumModels, BiologicalOrganelles/ metabolismSarcoplasmic Reticulum
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PMID: 1649772
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