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ChT1, an Ig superfamily molecule required for T cell differentiation

Katevuo, K.
Boyd, R.
Chidgey, A.
Bean, A.
Dunon, D.
Gobel, T. W.
Vainio, O.
Published in Journal of Immunology. 1999, vol. 162, no. 10, p. 5685-5694
Abstract The thymus is colonized by circulating progenitor cells that differentiate into mature T cells under the influence of the thymic microenvironment. We report here the cloning and function of the avian thymocyte Ag ChT1, a member of the Ig superfamily with one V-like and one C2-like domain. ChT1-positive embryonic bone marrow cells coexpressing c-kit give rise to mature T cells upon intrathymic cell transfer. ChT1-specific Ab inhibits T cell differentiation in embryonic thymic organ cultures and in thymocyte precursor cocultures on stromal cells. Thus, we provide clear evidence that ChT1 is a novel Ag on early T cell progenitors that plays an important role in the early stages of T cell development.
Keywords Amino Acid SequenceAnimalsAntigens, CD5/genetics/ immunologyAntigens, Surface/geneticsBase SequenceBone Marrow TransplantationCell DifferentiationChick EmbryoChickensCloning, MolecularDNA, Complementary/geneticsHematopoietic Stem Cells/immunologyImmunoglobulins/genetics/ immunologyLymphoid Tissue/embryology/immunologyMembrane Proteins/geneticsMolecular Sequence DataOrgan Culture TechniquesProto-Oncogene Proteins c-kit/isolation & purificationSequence Analysis, DNASequence Homology, Amino AcidT-Lymphocytes/ cytology/ immunologyThymus Gland/cytology/ immunology/surgeryTissue Distribution
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PMID: 10229800
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