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The occurrence of antibodies against single-stranded DNA in the sera of patients with acute and chronic leukaemia

Carpentier, N.
Miescher, P. A.
Published in Clinical and Experimental Immunology. 1976, vol. 24, no. 3, p. 379-384
Abstract One hundred and seventy-five sera from thirty-three patients with acute myeloid leukaemia, forty-two patients with chronic myeloid leukaemia and twelve patients with acute lymphatic leukaemia were examined by a radioimmunological technique for the presence of antibodies against single-stranded and double-stranded DNA. The levels of single-stranded DNA binding activity was significantly higher in all three types of leukaemia compared to those of healthy controls. In contrast, none of these sera exhibited a positive reaction with double-stranded DNA. In some cases the level of serum anti-DNA antibodies increased after the decrease of the leucocyte count. The presence of anti-DNA antibodies in leukaemic patients may have some biological significance.
Keywords Antibodies, Neoplasm/analysisBCG VaccineDNA, Single-Stranded/ immunologyFemaleFollow-Up StudiesHumansHydroxyurea/therapeutic useImmunotherapyLeukemia, Lymphoid/ immunologyLeukemia, Myeloid/ immunology/therapyLeukemia, Myeloid, Acute/ immunologyLeukocyte CountMaleMycobacterium bovis/immunology
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