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Pulmonary dysfunction and impaired granulocyte homeostasis result in poor survival of Jam-C-deficient mice

Publié dansJournal of pathology, vol. 212, no. 2, p. 198-208
Date de publication2007
Résumé

Jam-C(-/-) mice exhibit growth retardation and multilobular pneumonia concomitant with poor survival of the mice under conventional housing conditions. The deficient mice present a mega-oesophagus and have altered airway responsiveness. In addition, the number of circulating granulocytes is increased in Jam-C(-/-) mice as compared to control animals. These phenotypes probably reflect the different functions of JAM-C expressed by endothelial and mesenchymal cells. Indeed, the deregulation in the number of circulating granulocytes is caused by the lack of JAM-C expression on endothelial cells since rescuing endothelial expression of the protein in the Jam-C(-/-) mice is sufficient to restore homeostasis. More importantly, the rescue of vascular JAM-C expression is accompanied by better survival of deficient mice, suggesting that endothelial expression of JAM-C is mandatory for animal survival from opportunistic infections and fatal pneumonia.

Mots-clés
  • Animals
  • Bronchi/immunology
  • Cell Adhesion Molecules/analysis/ deficiency/immunology
  • Disease Susceptibility/immunology
  • Endothelial Cells/immunology
  • Esophageal Achalasia/immunology/physiopathology
  • Esophagus/immunology/physiopathology
  • Granulocytes/ immunology
  • Homeostasis/ immunology
  • Immunoglobulins/analysis/ deficiency/immunology
  • Immunohistochemistry/methods
  • Leukocyte Count
  • Lung/ immunology/physiopathology
  • Membrane Proteins/analysis/ deficiency/immunology
  • Mice
  • Mice, Mutant Strains
  • Muscle, Smooth/immunology
  • Neutrophils/immunology
  • Peritonitis/immunology/physiopathology
  • Pneumonia/immunology
  • Receptors, CXCR4/analysis
Structure d'affiliation Pas une publication de l'UNIGE
Citation (format ISO)
IMHOF, Beat et al. Pulmonary dysfunction and impaired granulocyte homeostasis result in poor survival of Jam-C-deficient mice. In: Journal of pathology, 2007, vol. 212, n° 2, p. 198–208. doi: 10.1002/path.2163
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Article
accessLevelRestricted
Identifiants
ISSN du journal0022-3417
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Création27.08.2010 13:34:54
Première validation27.08.2010 13:34:54
Heure de mise à jour14.03.2023 16:03:44
Changement de statut14.03.2023 16:03:43
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