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A score identifying serious bacterial infections in children with fever without source

Published in Pediatric Infectious Disease Journal. 2008, vol. 27, no. 7, p. 654-656
Abstract The objective of the study was to develop a simple clinical tool to identify serious bacterial infection (SBI) in children with fever without a source. For each child, a clinical assessment, a white blood cell count, a urine analysis, a determination of C-reactive protein, procalcitonin, and appropriate cultures were performed. Two hundred two children were studied of whom 54 (27%) had SBI. In the multivariate analysis, only procalcitonin [odds ratio (OR): 37.6], C-reactive protein (OR: 7.8), and urine dipstick (OR: 23.2) remained significantly associated with SBI. The sensitivity of the score for the identification of SBI was 94% and the specificity 81%. In the validation set the sensitivity of the score was 94% and the specificity 78%.
Keywords Bacteria/isolation & purificationBacterial Infections/diagnosis/pathology/physiopathologyC-Reactive Protein/analysisCalcitonin/bloodChild, PreschoolFever of Unknown Origin/etiologyHumansInfantInfant, NewbornLeukocyte CountProtein Precursors/bloodSensitivity and SpecificityUrinalysis
Stable URL http://archive-ouverte.unige.ch/unige:1133
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PMID: 18536624
Research group Etiologie des pneumonies et marqueurs inflammatoires chez l'enfant fébrile (183)
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