UNIGE document Scientific Article
previous document  unige:11305  next document
add to browser collection

The myofibroblast: one function, multiple origins

Phan, S. H.
Thannickal, V. J.
Galli, Andrea
Published in American Journal of Pathology. 2007, vol. 170, no. 6, p. 1807-1816
Abstract The crucial role played by the myofibroblast in wound healing and pathological organ remodeling is well established; the general mechanisms of extracellular matrix synthesis and of tension production by this cell have been amply clarified. This review discusses the pattern of myofibroblast accumulation and fibrosis evolution during lung and liver fibrosis as well as during atheromatous plaque formation. Special attention is paid to the specific features characterizing each of these processes, including the spectrum of different myofibroblast precursors and the distinct pathways involved in the formation of differentiated myofibroblasts in each lesion. Thus, whereas in lung fibrosis it seems that most myofibroblasts derive from resident fibroblasts, hepatic stellate cells are the main contributor for liver fibrosis and media smooth muscle cells are the main contributor for the atheromatous plaque. A better knowledge of the molecular mechanisms conducive to the appearance of differentiated myofibroblasts in each pathological situation will be useful for the understanding of fibrosis development in different organs and for the planning of strategies aiming at their prevention and therapy.
Keywords AnimalsAtherosclerosis/pathologyCell LineageExtracellular Matrix/metabolismFibroblasts/cytology/ physiologyFibrosis/pathologyLiver/cytology/pathologyLung/cytology/pathologyMuscles/ cytologyMyoblasts/cytology/ physiologyWound Healing/physiology
Stable URL http://archive-ouverte.unige.ch/unige:11305
Full text
PMID: 17525249
138 hits and 1 download since 2010-08-27
Export document
Format :
Citation style :