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Decreased blood pressure in NOX1-deficient mice

Deffert, Christine
Fiette, Laurence
Published in FEBS Letters. 2006, vol. 580, no. 2, p. 497-504
Abstract To understand the role of the superoxide-generating NADPH oxidase NOX1 in the vascular system, we have generated NOX1-deficient mice. NOX1-deficient mice had a moderately decreased basal blood pressure. In response to angiotensin II they showed an almost complete loss of the sustained blood pressure response, while the initial increase was conserved. NOX1-deficient mice showed a marked reduction in aortic media hypertrophy. Angiotensin II-induced smooth muscle cell proliferation was conserved, but there was a marked decrease in extracellular matrix accumulation. Our results establish a role for NOX1 in blood pressure regulation and vascular angiotensin II response.
Keywords Angiotensin II/pharmacologyAnimalsBlood Pressure/drug effects/ physiologyCell ProliferationExtracellular Matrix/metabolismFemaleHypotension/ metabolismMaleMiceInbred C57BLKnockoutMuscleSmoothVascular/cytologyNADHNADPH Oxidoreductases/genetics/ metabolismSignal Transduction/physiologyTunica Media/anatomy & histology/drug effects/pathology
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PMID: 16386251
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