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Use of the rapid antigenic test to determine the duration of isolation in infants hospitalized for respiratory syncytial virus infections

Myers, Catherine
Published in Clinical Pediatrics. 2008, vol. 47, no. 5, p. 493-495
Abstract Infants hospitalized for bronchiolitis associated with respiratory syncytial virus are isolated for the duration of their hospitalization. This article reviews whether a negative rapid antigenic test could be used to shorten the duration of isolation measures. Rapid respiratory syncytial virus tests were performed from day 3 on alternate days in all patients hospitalized for bronchiolitis. Isolation measures were removed when the test result was negative. The result of the antigenic test was confirmed by viral culture and polymerase chain reaction. Surveillance of nosocomial cases was performed daily. Forty-one patients were analyzed. On day 3, 51.2% of patients were negative by viral culture and 56.1% were negative by rapid testing. On day 5, a further 26.8% were negative by viral culture and 31.7% by rapid testing. The rapid antigen test had a low sensitivity at 60% and a specificity of 76% compared with viral cultures; therefore this test alone cannot be used to lift isolation measures.
Keywords Antigens, Viral/analysisBronchiolitis, Viral/therapyChild, PreschoolCross Infection/prevention & controlHospitalizationHumansPatient Isolation/standardsPolymerase Chain ReactionRespiratory Syncytial Virus Infections/therapyRespiratory Syncytial Virus, Human/immunology/isolation & purificationSensitivity and SpecificityTime Factors
Stable URL http://archive-ouverte.unige.ch/unige:1126
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PMID: 18509148
Research groups Etiologie des pneumonies et marqueurs inflammatoires chez l'enfant fébrile (183)
Groupe Laurent Kaiser (virologie clinique) (668)
Groupe Posfay-Barbe Clara (pédiatrie générale) (853)
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