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Title

In vivo myocardial infarct area at risk assessment in the rat using manganese enhanced magnetic resonance imaging (MEMRI) at 1.5T

Authors
Tatar, I.
Ivancevic, M K.
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Published in Magnetic Resonance in Medicine. 2008, vol. 59, no. 6, p. 1422-1430
Abstract The aim of this study was to measure the myocardial area at risk in rat, using MRI and manganese injection during a coronary occlusion/reperfusion model at 1.5T. A sequential protocol with occlusion and MnCl2 injection immediately followed by MRI was used with the assumption that MnCl2-induced contrast persistence is enough to accurately image the area at risk 90 min after occlusion. A total of 15 adult rats underwent a single 30-min episode of coronary occlusion followed by reperfusion. MnCl2 was injected (25 micromol/kg) at the beginning of the occlusion for 11 rats (group 1) and 6 h after reperfusion for four animals (group 2). A deficit of signal enhancement was observed in all rats. Hypoenhancement area in group 1 was correlated to the area at risk delineated by methylene blue (r=0.96, P<0.0001) whereas in group 2 it was correlated to the infarct area given by triphenyltetrazolium chloride (TTC) solution (r=0.98, P=0.003). The area at risk size was significantly correlated with left ventricle ejection fraction (LVEF), end-systolic volume and anterolateral wall thickening. This work demonstrates that hypoenhanced zone obtained after manganese injection during occlusion represents the area at risk and not only the infarct zone.
Keywords Analysis of VarianceAnimalsChlorides/diagnostic useContrast MediaDisease Models, AnimalElectrocardiographyImage Enhancement/methodsImage Processing, Computer-Assisted/methodsMagnetic Resonance Imaging/methodsManganese Compounds/diagnostic useMyocardial Infarction/pathologyRatsRats, Sprague-DawleyRisk Assessment
Stable URL http://archive-ouverte.unige.ch/unige:1125
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Identifiers
PMID: 18506788
Structures
Research group Imagerie cardiaque fonctionnelle (541)

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Deposited on : 2009-03-11

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