Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts
ContributorsFineschi, Serena; Reith, Walter; Guerne, P. A.; Dayer, Jean-Michel; Chizzolini, Carlo
Published inThe FASEB journal, vol. 20, no. 3, p. 562-564
Publication date2006
Abstract
Keywords
- Acetylcysteine/ analogs & derivatives/pharmacology
- Anthracenes/pharmacology
- Boronic Acids/ pharmacology
- Collagen Type I/ biosynthesis/genetics
- Dose-Response Relationship, Drug
- Down-Regulation/drug effects
- Extracellular Matrix/metabolism
- Fibroblasts/ drug effects/metabolism
- Fibrosis
- Genes, jun
- Humans
- JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors/metabolism
- Leupeptins/ pharmacology
- Matrix Metalloproteinase 1/ biosynthesis/genetics
- Phosphorylation/drug effects
- Proteasome Endopeptidase Complex/ antagonists & inhibitors/physiology
- Protein Processing, Post-Translational/drug effects
- Proto-Oncogene Proteins c-jun/metabolism
- Pyrazines/ pharmacology
- RNA Polymerase II/antagonists & inhibitors
- RNA, Messenger/biosynthesis/genetics
- Scleroderma, Systemic/ metabolism
- Skin/cytology
- Tissue Inhibitor of Metalloproteinase-1/ biosynthesis/genetics
- Transforming Growth Factor beta/pharmacology
- Up-Regulation/drug effects
Affiliation Not a UNIGE publication
Citation (ISO format)
FINESCHI, Serena et al. Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts. In: The FASEB journal, 2006, vol. 20, n° 3, p. 562–564. doi: 10.1096/fj.05-4870fje
Main files (1)
Article
Identifiers
- PID : unige:11246
- DOI : 10.1096/fj.05-4870fje
- PMID : 16410344
Commercial URLhttp://www.fasebj.org/cgi/reprint/05-4870fjev1.pdf
ISSN of the journal0892-6638