UNIGE document Scientific Article
previous document  unige:11222  next document
add to browser collection

Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins

Doyle, J.
Hoffman, S.
Ucla, C.
Stubbs, L.
Published in Genomics. 1996, vol. 35, no. 1, p. 227-230
Abstract RFX transcription factors constitute a highly conserved family of site-specific DNA binding proteins involved in the expression of a variety of cellular and viral genes, including major histocompatibility complex class II genes and genes in human hepatitis B virus. Five members of the RFX gene family have been isolated from human and mouse, and all share a highly characteristic DNA binding domain that is distinct from other known DNA binding motifs. The human RFX1 and RFX2 genes have been assigned by in situ hybridization to chromosome 19p13.1 and 19p13.3, respectively. In this paper, we present data that localize RFX1 and RFX2 precisely within the detailed physical map of human chromosome 19 and genetic data that assign Rfx1 and Rfx2 to homologous regions of mouse chromosomes 8 and 17, respectively. These data define the established relationships between these homologous mouse and human regions in further detail and provide new tools for linking cloned genes to phenotypes in both species.
Keywords AnimalsBase SequenceChromosome MappingChromosomes, Human, Pair 19/ geneticsCrosses, GeneticDNA-Binding Proteins/ geneticsGenesGenes, junHumansIn Situ HybridizationLinkage (Genetics)Mice/ geneticsMolecular Sequence DataMultigene FamilyMuridae/geneticsTranscription Factors/ genetics
Stable URL http://archive-ouverte.unige.ch/unige:11222
Full text
PMID: 8661125
148 hits and 0 download since 2010-08-27
Export document
Format :
Citation style :