Scientific Article
previous document  unige:11220  next document
add to browser collection

TWEAK is expressed by glial cells, induces astrocyte proliferation and increases EAE severity

Desplat-Jego, Sophie
Varriale, Simone
Creidy, Rita
Terra, Rafik
Bernard, Dominique
Khrestchatisky, Michel
show hidden authors show all authors [1 - 9]
Published in Journal of Neuroimmunology. 2002, vol. 133, no. 1-2, p. 116-123
Abstract TWEAK is a new TNF family member with proinflammatory and proliferative effects on different cell types, mediated by the recently identified Fn14 receptor. TWEAK expression was analyzed on mouse microglial cells and astrocytes. Both cell types express TWEAK mRNA. Astrocytes expressed Fn14 and proliferated in the presence of rTWEAK. TWEAK mRNA is expressed in normal CNS and its steady state level increases in spinal cord during EAE. Finally, EAE severity is enhanced in soluble TWEAK-overexpressing transgenic mice. These results support the contention that TWEAK is involved in CNS inflammation.
Keywords AnimalsApoptosis Regulatory ProteinsAstrocytes/immunology/ metabolismCarrier Proteins/ genetics/pharmacologyCell Division/drug effects/genetics/immunologyCells, CulturedCentral Nervous System/growth & development/immunology/ metabolismDisease ProgressionDisease Susceptibility/immunologyEncephalomyelitis, Autoimmune, Experimental/genetics/immunology/ metabolismGene Expression Regulation/immunologyInflammation Mediators/ pharmacologyMiceMice, TransgenicMicroglia/immunology/ metabolismRNA, Messenger/immunology/metabolismTumor Necrosis Factors
Stable URL
Full text
PMID: 12446014
136 hits and 0 download since 2010-08-27
Export document
Format :
Citation style :