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Long-term control with etanercept (Enbrel) of a severe acrodermatitis continua of Hallopeau refractory to infliximab (Remicade)

Thielen, A-M.
Barde, C.
Marazza, G.
Published in Dermatology. 2008, vol. 217, no. 2, p. 137-9
Abstract Hallopeau's acrodermatitis is characterized by the presence of aseptic pustules on an inflammatory basis of the periungual or subungual region. The cyclic recurrences induce important physical and psychological morbidity. By analogy to the efficacy of TNF-alpha antagonists in the treatment of generalized pustular psoriasis, our patient illustrates the long-term efficacy and safety of etanercept (Enbrel) in the treatment of Hallopeau's acrodermatitis refractory to infliximab (Remicade). This treatment alternative should in consequence be considered in patients with a recalcitrant form of a potentially debilitating disease.
Keywords Acrodermatitis/diagnosis/drug therapyDose-Response Relationship, DrugDrug Administration ScheduleFollow-Up StudiesHand Dermatoses/diagnosis/drug therapyHumansImmunoglobulin G/therapeutic useMaleMiddle AgedReceptors, Tumor Necrosis Factor/therapeutic useRisk AssessmentSeverity of Illness IndexTime FactorsTreatment OutcomeTumor Necrosis Factor-alpha/antagonists & inhibitors/therapeutic use
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PMID: 18503258
Research groups La recherche en biochimie dermatologique (652)
Rôle du CD44 (809)
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