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Scientific article
English

Apoptosis participates in cellularity regulation during rat aortic intimal thickening

Published inThe American journal of pathology, vol. 146, no. 5, p. 1059-1064
Publication date1995
Abstract

Intimal thickening induced after endothelial denudation of rat aorta is though to be due to migration and proliferation of smooth muscle cells (SMC). When the reendothelialization is achieved, intimal thickening shows an important decrease in cellularity. Using in situ end labeling of fragmented DNA and electron microscopy, we show that this remodeling is accompanied by apoptosis of SMC. The number of apoptotic SMC becomes important 15 days after endothelial injury and reaches a maximum at 20 days; at 45 days the intimal thickening is reendothelialized and no more apoptotic SMC are detected. Apoptotic SMC show nuclear and cytoplasmic condensation as well as cytoplasmic vacuolization. Our results indicate that apoptosis is an important mechanism in the regulation of intimal thickening evolution.

Keywords
  • Animals
  • Aorta/pathology
  • Apoptosis/ physiology
  • Arteriosclerosis/ pathology
  • Cell Division/ physiology
  • Endothelium, Vascular/pathology/ultrastructure
  • Immunoenzyme Techniques
  • Male
  • Muscle, Smooth, Vascular/pathology/ultrastructure
  • Rats
  • Rats, Wistar
  • Tunica Intima/ pathology
Citation (ISO format)
BOCHATON-PIALLAT, Marie-Luce et al. Apoptosis participates in cellularity regulation during rat aortic intimal thickening. In: The American journal of pathology, 1995, vol. 146, n° 5, p. 1059–1064.
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ISSN of the journal0002-9440
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