Pharmacogenetics of antidepressant response: A polygenic approach

Major Depressive DisorderWorking Group of the Psychiatric Genomic Consortium1

doi:10.1016/j.pnpbp.2017.01.011

Scientific article

English

Pharmacogenetics of antidepressant response: A polygenic approach

ContributorsMajor Depressive DisorderWorking Group of the Psychiatric Genomic Consortium1

CollaboratorsGarcía-González, Judit; Perroud, Nader Ali

; Bondolfi, Guido

Published inProgress in Neuro-psychopharmacology & Biological Psychiatry, vol. 75, p. 128-134

Publication date2017

Abstract

Major depressive disorder (MDD) has a high personal and socio-economic burden and >60% of patients fail to achieve remission with the first antidepressant. The biological mechanisms behind antidepressant response are only partially known but genetic factors play a relevant role. A combined predictor across genetic variants may be useful to investigate this complex trait.

Keywords

Antidepressive Agents/therapeutic use
Depressive Disorder, Major/drug therapy/genetics
Female
Genetic Association Studies
Humans
Male
Multifactorial Inheritance/genetics
Pharmacogenetics
Risk Factors
Schizophrenia/drug therapy/genetics

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de psychiatrie

Research groups

Citation (ISO format)

Major Depressive DisorderWorking Group of the Psychiatric Genomic Consortium1. Pharmacogenetics of antidepressant response: A polygenic approach. In: Progress in Neuro-psychopharmacology & Biological Psychiatry, 2017, vol. 75, p. 128–134. doi: 10.1016/j.pnpbp.2017.01.011

Article (Published version)

Identifiers

PID : unige:111388
DOI : 10.1016/j.pnpbp.2017.01.011
PMID : 28159590

Journal ISSN0278-5846

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Update time15/03/2023 13:54:47

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Pharmacogenetics of antidepressant response: A polygenic approach

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