Scientific Article
previous document  unige:11123  next document
add to browser collection

Role of interendothelial adhesion molecules in the control of vascular functions

Published in Vascular Pharmacology. 2002, vol. 39, no. 4-5, p. 239-246
Abstract The function of endothelium is the lining of the vessel wall and the control of vascular permeability, homeostasis and leukocyte emigration from the blood into the surrounding tissue. Different adhesion molecules expressed in a coordinated and regulated way control this function. In this review, we discuss adhesion molecules involved in endothelial junctions and their involvement in leukocyte transendothelial migration. Passage of the leukocyte across the endothelium appears to require delocalization of certain vascular adhesion molecules whereas other molecules interact directly with leukocyte ligands. Understanding of the function of vascular adhesion molecules is further complicated as they transduce signals to the endothelium and interact with the cytoskeleton and adaptor proteins.
Keywords AnimalsCell Adhesion Molecules/ physiologyCell Membrane Permeability/ physiologyChemotaxis, Leukocyte/ physiologyEndothelium, Vascular/ physiologySignal Transduction/physiologyTight Junctions/ physiology
Stable URL
Full text
PMID: 12747963
94 hits and 0 download since 2010-08-27
Export document
Format :
Citation style :