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Induction of HLA class II genes by IFN-gamma is transcriptional and requires a trans-acting protein

Amaldi, I.
Berte, C.
Published in Journal of Immunology. 1989, vol. 142, no. 3, p. 999-1004
Abstract HLA class II Ag are encoded by a family of related genes clustered in the HLA-D region of the MHC. The expression of this multi-gene family is highly regulated and this regulation is essential for the control of the immune response. Class II gene expression is constitutive in a limited number of cell types and can be induced by IFN-gamma in a number of class II negative cells. In this study, we have clarified two essential aspects of the regulation of HLA class II genes by IFN-gamma. 1) The induction mechanism operates at the level of transcription and there is a long lag phase in the signal transduction process. 2) The induction of class II genes requires the de novo synthesis of a new protein(s). On this basis, we propose that IFN-gamma regulates the transcription of HLA class II genes via the de novo synthesis of a trans-acting activator protein.
Keywords Antigens, Differentiation, B-LymphocyteCell LineGene Expression Regulation/ drug effectsGenes, MHC Class II/ drug effectsHLA-DR Antigens/ geneticsHistocompatibility Antigens Class II/geneticsHumansInterferon-gamma/ pharmacologyKineticsOsteosarcoma/geneticsProtein BiosynthesisTranscription Factors/ pharmacologyTranscription, Genetic/ drug effects
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Other version: http://www.jimmunol.org/cgi/reprint/142/3/999.pdf
PMID: 2492334
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