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Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene

Martinou, I.
Tsujimoto, Y.
Martinou, J. C.
Published in Science. 1992, vol. 258, no. 5080, p. 302-304
Abstract Approximately half of the neurons produced during embryogenesis normally die before adulthood. Although target-derived neurotrophic factors are known to be major determinants of programmed cell death--apoptosis--the molecular mechanisms by which trophic factors interfere with cell death regulation are largely unknown. Overexpression of the bcl-2 proto-oncogene in cultured sympathetic neurons has now been shown to prevent apoptosis normally induced by deprivation of nerve growth factor. This finding, together with the previous demonstration of bcl-2 expression in the nervous system, suggests that the Bcl-2 protein may be a major mediator of the effects of neurotrophic factors on neuronal survival.
Keywords AnimalsApoptosis/ geneticsCell Death/ geneticsCells, CulturedGanglia, Sympathetic/cytologyGene ExpressionHumansNerve Growth Factors/physiologyNeurons/ physiologyProto-Oncogene Proteins/ geneticsProto-Oncogene Proteins c-bcl-2RatsSympathetic Nervous System/ cytologyTransfection
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PMID: 1411528
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